Acetyl Hexapeptide-49
Acetyl Hexapeptide-49 is a synthetic peptide designed for use in skincare products, particularly those targeting sensitive, reactive, or irritated skin. It’s part of a class of ingredients known as neuro-calming peptides, which help reduce discomfort and visible signs of inflammation. Unlike peptides focused on anti-aging or firming, Acetyl Hexapeptide-49 primarily works to soothe skin, reduce redness, and improve barrier function.
This ingredient is often found in serums, moisturisers, and post-procedure products that aim to calm the skin and reduce sensitivity — making it ideal for people with rosacea, irritation, or reactive skin conditions, as well as those recovering from cosmetic treatments like laser or chemical peels.
What It Does in Skincare
- Reduces skin discomfort such as stinging, burning, and tightness by calming nerve endings and inflammation.
- Visibly reduces redness and blotchiness, helping to improve overall skin tone and reduce sensitivity-related flare-ups.
- Strengthens the skin barrier, making skin more resilient to environmental stressors and less prone to irritation over time.
- Improves hydration by supporting the skin’s natural moisture retention.
- Enhances comfort and smoothness, leaving skin feeling calmer, softer, and more balanced.
- Post-procedure support: Commonly used in products designed for use after dermatological treatments to reduce irritation and speed recovery.
Safety & Toxicology
- Very safe and well-tolerated, especially in sensitive or reactive skin types.
- Non-irritating and non-sensitising — does not typically cause redness, itching, or breakouts.
- Has undergone clinical testing, showing effectiveness in reducing sensory irritation and improving skin comfort.
- Can be used daily, and is suitable for long-term use.
- Vegan and cruelty-free when produced synthetically, with no animal-derived components.
- No known long-term safety concerns when used in topical cosmetic formulations at recommended concentrations.